A series of 3-(N-alkyl-N-phenylamino) propan-2-ol derivatives were synthesized from epichlorohydrine in a multi-step strategy and were evaluated as Src kinase inhibitors. First, epoxy ring opening of epichlorohydrine was carried out in the presence of N-alkylanilines to yield 3-(N-alkyl-N-phenylamino)-1-chloro-propan-2-ol derivatives using Ca (OTf) 2 as catalyst based on our previous studies [1]. Second, ring closure was performed under ...
