e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Development of a series of phenyltetrazole leukotriene D4 (LTD4) receptor antagonists
…, NG Bollinger, JS Sawyer, RF Baldwin…
Index: Harper, Richard W.; Herron, David K.; Bollinger, Nancy G.; Sawyer, J. Scott; Baldwin, Ronald F.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 7 p. 1191 - 1200
A hypahetical model for receptor binding of leukotriene D4 (LTD,) was deduced from conformational analysis of LTD, and from the structure-activity relationships (SAR) of known LTD, receptor antagonists. A new structural series of LTD4 receptor antagonists exemplified by 5 [4 (4phenylbutoxy) phenyl]-2-[4 (tetrazol-5yl) butyl]-W-tetrazole was designed in which a phenyltetrazole moiety was incorporated as a receptor binding equivalent of the triene ...
