General anesthetics. 1. Halogenated methyl ethyl ethers as anesthetic agents

RC Terrell, L Speers, AJ Szur, J Treadwell…

Index: Terrell; Speers; Szur; Treadwell; Ucciardi Journal of medicinal chemistry, 1971 , vol. 14, # 6 p. 517 - 519

Full Text: HTML

Citation Number: 55

Abstract

Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile general anesthetics. Eleveii of the ethers were too unstable t, o test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in larger animals. Those ethers having one H with at least 2 halogens other than F or 2 or more H with at least one Br or one C1 were the best anesthetics.