Abstract A convergent synthesis of bafilomycin A 1, a potent inhibitor of V-type ATPases, is presented. The synthesis relies on the zinc triflate mediated diastereoselective addition of a complex enyne to a sensitive aldehyde as the key fragment coupling. A ruthenium-catalyzed trans-reduction of the resulting propargylic enyne efficiently installs the required C10–C13 trans, trans-diene subunit, implementing an alternative strategy to traditional palladium- ...
[Gottumukkala, Aditya L.; Matcha, Kiran; Lutz, Martin; De Vries, Johannes G.; Minnaard, Adriaan J. Chemistry - A European Journal, 2012 , vol. 18, # 22 p. 6907 - 6914]
![(1S,2R)-2-[N-Benzyl-N-(mesitylenesulfonyl)amino]-1-phenylpropyl Propionate Structure](https://image.chemsrc.com/caspic/048/187324-67-0.png)
