e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis of [4??14C]??pelargonidin chloride and [4??14C]??delphinidin chloride

…, E Biskup, E Richling, P Schreier

Index: Kraus, Michael; Biskup, Ellen; Richling, Elke; Schreier, Peter Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 13 p. 1151 - 1162

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Citation Number: 7

Abstract

Abstract The synthesis of [4-14 C]-pelargonidin chloride and [4-14 C]-delphinidin chloride via [formyl-14 C]-2-(benzoyloxy)-4, 6-dihydroxybenzaldehyde, ω, 4-diacetoxyacetophenone and ω, 3, 4, 5-tetraacetoxyacetophenone is described. The first step comprised labelling of the carbonyl group of 2-(benzoyloxy)-4, 6-dihydroxybenzaldehyde, verifying that the coupling with ω, 4-diacetoxyacetophenone or ω, 3, 4, 5-tetraacetoxyacetophenone under ...

2,4,6-Trihydroxybenzaldehyde Structure

2,4,6-Trihydrox...

Benzoyl chloride Structure

Benzoyl chloride

~21%

2-Benzoyloxy-4,6-dihydroxybenzaldehyde Structure

2-Benzoyloxy-4,...

(2,3-diacetyloxy-5-carbonochloridoylphenyl) acetate Structure

(2,3-diacetylox...

~%

Delphinidin chloride Structure

Delphinidin chloride

Benzoic acid,3,4,5-tris(acetyloxy)- Structure

Benzoic acid,3,...

~%

Delphinidin chloride Structure

Delphinidin chloride

Gallic acid Structure

~%

Delphinidin chloride Structure

Delphinidin chloride

2,4,6-Trihydroxybenzaldehyde Structure

2,4,6-Trihydrox...

~%

Delphinidin chloride Structure

Delphinidin chloride

2-Benzoyloxy-4,6-dihydroxybenzaldehyde Structure

2-Benzoyloxy-4,...

~%

Delphinidin chloride Structure

Delphinidin chloride

Ethanone, 2-chloro-1-[3,4,5-tris(acetyloxy)phenyl]- Structure

Ethanone, 2-chl...

~%

Delphinidin chloride Structure

Delphinidin chloride

N/A Structure

~%

Delphinidin chloride Structure

Delphinidin chloride

Ethanone,2-(acetyloxy)-1-[3,4,5-tris(acetyloxy)phenyl]- Structure

Ethanone,2-(ace...

~%

Delphinidin chloride Structure

Delphinidin chloride

Ethanone, 2-chloro-1-[3,4,5-tris(acetyloxy)phenyl]- Structure

Ethanone, 2-chl...

Ethanoic anhydride Structure

Ethanoic anhydride

~75%

Ethanone,2-(acetyloxy)-1-[3,4,5-tris(acetyloxy)phenyl]- Structure

Ethanone,2-(ace...

(2,3-diacetyloxy-5-carbonochloridoylphenyl) acetate Structure

(2,3-diacetylox...

~%

Ethanone,2-(acetyloxy)-1-[3,4,5-tris(acetyloxy)phenyl]- Structure

Ethanone,2-(ace...

Benzoic acid,3,4,5-tris(acetyloxy)- Structure

Benzoic acid,3,...

~%

Ethanone,2-(acetyloxy)-1-[3,4,5-tris(acetyloxy)phenyl]- Structure

Ethanone,2-(ace...

Gallic acid Structure

~%

Ethanone,2-(acetyloxy)-1-[3,4,5-tris(acetyloxy)phenyl]- Structure

Ethanone,2-(ace...

N/A Structure

~%

Ethanone,2-(acetyloxy)-1-[3,4,5-tris(acetyloxy)phenyl]- Structure

Ethanone,2-(ace...

α,α-dimethyl-p-hydroxyphenacyl acetate Structure

α,α-dimethyl-p-...

Ethanoic anhydride Structure

Ethanoic anhydride

~77%

4-(2-acetoxyacetyl)phenyl acetate Structure

4-(2-acetoxyace...

2-Chloro-1-(4-hydroxyphenyl)ethanone Structure

2-Chloro-1-(4-h...

~%

4-(2-acetoxyacetyl)phenyl acetate Structure

4-(2-acetoxyace...

Anisole Structure

~%

4-(2-acetoxyacetyl)phenyl acetate Structure

4-(2-acetoxyace...

2-Chloro-1-(4-methoxyphenyl)ethanone Structure

2-Chloro-1-(4-m...

~%

4-(2-acetoxyacetyl)phenyl acetate Structure

4-(2-acetoxyace...

2-Chloro-1-(4-methoxyphenyl)ethanone Structure

2-Chloro-1-(4-m...

~%

2-Chloro-1-(4-hydroxyphenyl)ethanone Structure

2-Chloro-1-(4-h...