Scale-up synthesis of the dopamine uptake inhibitor GBR-12909

MD Ironside, PM Sugathapala…

Index: Organic Process Research and Development, , vol. 6, # 5 p. 621 - 627

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Citation Number: 2

Abstract

... As per intermediate 2, it was discovered that crude dihydrochloride salt could be formed more efficiently by treating the organic extracts with 2.2 equiv of concentrated hydrochloric acid at 20 ... This new procedure eliminated 1,4-dioxane from the process and simplified ...