The Journal of organic chemistry

Suzuki cross-coupling/reductive debenzyloxycarbonylation sequence for the syntheses of [c] annulated isoquinolines: Application for the syntheses of pancratistatin- …

G Pandey, M Balakrishnan

Index: Pandey, Ganesh; Balakrishnan, Madhesan Journal of Organic Chemistry, 2008 , vol. 73, # 20 p. 8128 - 8131

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Citation Number: 35

Abstract

A two-step strategy involving Suzuki cross-coupling of boronic acids with a diverse array of α- iodoenones followed by hydrogenation is developed for the construction of [c] annulated isoquinolines. This mild and efficient procedure is also applied to the synthesis of highly oxygenated isoquinolines.