Synthesis and anticancer evaluation of thiazolyl–chalcones

HB Shi, SJ Zhang, QF Ge, DW Guo, CM Cai…

Index: Shi, Hai-Bo; Zhang, Shi-Jie; Ge, Qiu-Fu; Guo, Dian-Wu; Cai, Chao-Ming; Hu, Wei-Xiao Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 22 p. 6555 - 6559

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Citation Number: 23

Abstract

Thirty-seven (E)-1-(4-methyl-2-arylaminothiazol-5-yl)-3-arylprop-2-en-1-ones were synthesized via Claisen-Schmidt condensation of 1-(4-methyl-2-(arylamino) thiazol-5-yl) ethanone with the corresponding arylaldehydes. All these thiazolyl–chalcones were characterized and evaluated by MTT assay on human cancer cell lines BGC-823, PC-3, NCI- H460, BEL-7402 in vitro. Compounds 5, 8, 26, 37 and 41 are effective against cancer cell ...