e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Design, Synthesis, and Biological Evaluation of 14-Heteroaromatic-Substituted Naltrexone Derivatives: Pharmacological Profile Switch from Mu Opioid Receptor …
…, SA Zaidi, O Elbegdorj, LCK Aschenbach…
Index: Yuan, Yunyun; Zaidi, Saheem A.; Elbegdorj, Orgil; Aschenbach, Lindsey C. K.; Li, Guo; Stevens, David L.; Scoggins, Krista L.; Dewey, William L.; Selley, Dana E.; Zhang, Yan Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9156 - 9169
On the basis of a mu opioid receptor (MOR) homology model and the isosterism concept, three generations of 14-heteroaromatically substituted naltrexone derivatives were designed, synthesized, and evaluated as potential MOR-selective ligands. The first- generation ligands appeared to be MOR-selective, whereas the second and the third generation ones showed MOR/kappa opioid receptor (KOR) dual selectivity. Docking of ...
[Dokuzovic, Zdravko; Roberts, Nicholas K.; Sawyer, Jeffery F.; Whelan, John; Bosnich, B. Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 2034 - 2039]
