Australian journal of chemistry

Synthesis and radiolabelling of ipratropium and tiotropium for use as pet ligands in the study of inhaled drug deposition

F Issa, M Kassiou, HK Chan, MD McLeod

Index: Issa, Fatiah; Kassiou, Michael; Chan, Hak-Kim; McLeod, Malcolm D. Australian Journal of Chemistry, 2006 , vol. 59, # 1 p. 53 - 58

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Citation Number: 6

Abstract

Abstract Ipratropium bromide [(1R, 3r, 5S, 8r, 2′ RS)-3-(3′-hydroxy-2′- phenylpropionyloxy)-8-isopropyl-8-methyl-8-azabicyclo [3.2. 1] octan-8-ium bromide] and tiotropium bromide [(1R, 2R, 4S, 5S, 7s)-7-[2′-hydroxy-2′, 2′-di (thiophen-2′′-yl) acetoxy]-9, 9-dimethyl-9-aza-3-oxatricyclo [3.3. 1.0 2, 4] nonan-9-ium bromide] are inhaled drugs used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma ...