Tetrahedron Letters

One-pot copper-catalyzed synthesis of N-functionalized pyrazoles from boronic acids

RE Beveridge, D Fernando, BS Gerstenberger

Index: Beveridge, Ramsay E.; Fernando, Dilinie; Gerstenberger, Brian S. Tetrahedron Letters, 2010 , vol. 51, # 38 p. 5005 - 5008

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Citation Number: 14

Abstract

A straight-forward route to prepare a diverse set of N-aryl pyrazoles via a one-pot copper- catalyzed boronic acid coupling and cyclization protocol is presented. A variety of aryl and heteroaryl N-functionalized pyrazoles not easily accessible by other means were formed in good yield from readily available boronic acid precursors in an operationally simple procedure.