3, 4-Dihydroquinolin-2 (1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase

GR Martinez, KAM Walker, DR Hirschfeld…

Index: Martinez; Walker; Hirschfeld; Bruno; Yang; Maloney Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 620 - 628

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Citation Number: 51

Abstract

A series of lH-imidazol-1-yl-and 3-pyridyl-substituted 3, 4dihydroquinolin-2 (lH)-onea was designed and syntheaized as combied inhibitors of thromboxane ('I'XAJ synthase and CAMP phosphodiesterase (PDE) in human blood plateleta. A number of struh, eg 4b, 7a, 7e, 13a, and 21-25, were superior to dazoxiben 26 as inhibitore of TXG, synthase in in vitro ADP- indud aggregation experiments with human blood platelets. The TXA, synthase inhibitory ...