Abstract Most of the G-quadruplex interactive molecules reported to date contain extended aromatic flat ring systems and are believed to bind principally by π–π stacking on the end G- tetrads of the quadruplex structure. One such molecule, TMPyP4,(5, 10, 15, 20-tetra (N- methyl-4-pyridyl) porphyrin), exhibits high affinity and some selectivity for G-quadruplex DNA over duplex DNA. Although not a realistic drug candidate, TMPyP4 is used in many ...
