Synthesis, pharmacological screening, quantum chemical and in vitro permeability studies of N-Mannich bases of benzimidazoles through bovine cornea

…, P Shanmugapandiyan, M Inayathullah, V Arul…

Index: Jesudason, E. Philip; Sridhar; Malar, E.J. Padma; Shanmugapandiyan; Inayathullah, Mohammed; Arul; Selvaraj; Jayakumar European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 2307 - 2312

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Citation Number: 31

Abstract

A novel series of N-Mannich bases of benzimidazole derivatives were synthesized and characterized by 1H NMR, IR spectral studies and elemental analysis. The compounds were screened for analgesic and anti-inflammatory activity. 1-((Diethylamino)-methyl)-2-styryl benzimidazole 4 at 40mg/kg was found to be equipotent to paracetamol. 1-((Piperidin-1-yl) methyl)-2-styryl-benzimidazole 6 at 40mg/kg was found to be more potent than Diclofenac. ...