Asymmetric Synthesis of 2-chloro-and 2-bromo-alkanoic acids by halogenation of α-D-glucofuranose-derived silyl ketene acetals

…, JL Chaumette, JR Desmurs, L Duhamel, G Plé…

Index: Angibaud, P.; Chaumette, J. L.; Desmurs, J. R.; Duhamel, L.; Ple, G.; et al. Tetrahedron: Asymmetry, 1995 , vol. 6, # 8 p. 1919 - 1932

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Citation Number: 16

Abstract

Optically active (S)-2-bromo-and 2-chloro-alkanoic acids 6 and 7 have been obtained via the diastereoselective halogenation of chiral silyl ketene acetals 3a-f, and subsequent saponification of the resulting crude esters. Examples characterized by ee values up to 95 ...