Abstract: The biosynthesis of aplasmomycin in Streptomyces griseus strain SS-20 was studied by feeding experiments with I3C-labeled precursors. I3C NMR analysis of the antibiotic samples biosynthesized from [1-I3C]-,[2-I3C]-, and [1, 2-'3C2] acetate and from [I3CH3] methionine showed that each half of the molecule is made up from seven intact acetate units providing carbons 1-14 and three methyl groups originating from methionine, ...
