Synthesis of a new family of protected 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-triacetic acid derivatives with thioctic acid pending arms

…, F Lachaud, F Chuburu, C Cadiou, G Lemercier

Index: De La Reberdiere, Arnaud; Lachaud, Fabien; Chuburu, Francoise; Cadiou, Cyril; Lemercier, Gilles Tetrahedron Letters, 2012 , vol. 53, # 45 p. 6115 - 6118,4

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Citation Number: 3

Abstract

The synthesis and characterization of a new family of ester protected N-substituted [1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-triacetic acid (H3DO3A) derivatives containing a pendant thioctic acid (α lipoic acid, LA) are reported. These compounds (DO3AtBu-NLA, DO3AtBu- NMeNLA, and DO3AtBu-NEtNLA) are suitable for the functionalization of gold surfaces with rare-earth complexes.