Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors

Y Yin, L Lin, C Ruiz, S Khan, MD Cameron…

Index: Journal of Medicinal Chemistry, , vol. 56, # 9 p. 3568 - 3581

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Citation Number: 19

Abstract

... Journal of Medicinal ... Medicinal Chemistry; ‡ Discovery Biology; ∞ Crystallography/Modeling Facility; § Drug Metabolism and Pharmacokinetics, Translational Research Institute ... relationship (SAR) studies and for modifying the inhibitor's overall pharmaceutical properties, such ...

Structure–activity relationships of novel substituted naphth...

[Milelli, Andrea; Tumiatti, Vincenzo; Micco, Marialuisa; Rosini, Michela; Zuccari, Guendalina; Raffaghello, Lizzia; Bianchi, Giovanna; Pistoia, Vito; Fernando Diaz; Pera, Benet; Trigili, Chiara; Barasoain, Isabel; Musetti, Caterina; Toniolo, Marianna; Sissi, Claudia; Alcaro, Stefano; Moraca, Federica; Zini, Maddalena; Stefanelli, Claudio; Minarini, Anna European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 417 - 428]