Biological and anti-inflammatory evaluation of two thiazole compounds in RAW cell line: potential cyclooxygenase-2 specific inhibitors

…, A Habib, A Hachem, AH Hussein, M Abbas…

Index: Hamade, Eva; Habib, Aida; Hachem, Ali; Hussein, Alaa H.; Abbas, Malak; Hirz, Taghreed; Al Masri, Mirvat; Faour, Wissam H. Medicinal Chemistry, 2012 , vol. 8, # 3 p. 401 - 408

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Citation Number: 5

Abstract

The anti-inflammatory effect of two new thiazoles derivatives CX-32 (N-[4-(4-hydroxy-3- methoxyphenyl)-1, 3-thiazol-2-yl] acetamide) and CX-35 (4-(2-amino-1, 3-thiazol-4-yl)-2- methoxyphenol), was investigated in LPS-stimulated RAW 264.7 cell line. Synthesis, structure analysis and purity of these compounds were evaluated by high performance liquid chromatography, H1 NMR, and C13 NMR. Assessment of CX-32 and CX-35 inhibitory ...