Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural …

…, Y Ishikawa, S Takamizawa, A Eng, R Sakai…

Index: Katritzky, Alan R.; Sutharchanadevi, Murugan; Urogdi, Laszlo Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 1847 - 1851

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Citation Number: 14

Abstract

... Journal of Medicinal ... Chemical Synthesis The asymmetric synthesis was carried out on the basis of our route for 12 glutamate analogues,(7-10) which was ... By use of (R)-amine 3 prepared in 48% yield over five steps from (R)-(4-hydroxyphenyl)glycine,(14) an oxanorbornene ...