Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone

…, MJ Curtis-Long, CW Lee, HW Ryu, KC Jang…

Index: Seo, Woo Duck; Ryu, Young Bae; Curtis-Long, Marcus J.; Lee, Chan Woo; Ryu, Hyung Won; Jang, Ki Chang; Park, Ki Hun European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 2010 - 2017

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Citation Number: 48

Abstract

The 4′-(p-toluenesulfonylamino)-4-hydroxychalcone (TSAHC), which bears inhibitory chemotypes for both α-glucosidase and tyrosinase, was evaluated for tyrosinase activity and depigmenting ability relative to compounds designed to only target tyrosianse activity. TSAHC emerged to be a competitive reversible inhibitor of mushroom tyrosinase. More importantly, it was also able to return the melanin content of α-melanocyte stimulated by α- ...