was preferable to the coupling of N-benzyloxycarbonyl-L-phenylalanyl-L-alanine15 with 3 by method A. Catalytic hydrogenolysis with 5% Pd-C was used generally to remove the blocking groups to afford the final nucleoside peptides, all obtained as solvated solids. HOAc was added to aid in the deblocking of the arginyl derivative 11. The blocked glutamyl nucleoside 15 was first hydrogenolyzed to remove the y-benzyl ester, then the t- ...
