e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
A simple two-step synthesis of avenanthramides, constituents of oats (Avena sativa L)
SP Kamat, SJ Parab
Index: Kamat, Shrivallabh P.; Parab, Sulaksha J. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 12 p. 2074 - 2078
Abstract: A simple two-step general procedure has been developed to prepare naturally occurring and synthetic avenanthramides, constituents of oats (Avena sativa L). Reaction of anthranilic acid 1 with Meldrum's acid 2 gives half amide of malonic acid 3 which on condensation with different benzaldehyde derivatives 4a-m gives avenanthramides 5a-m of which 5a-d are natural, 5e-g are their methyl ethers and 5h-m are synthetic.
