Palladium-Catalyzed Cross Coupling Reaction of N-Alkoxyimidoyl Bromides and Its Application to One-Pot Synthesis of N-Arylamines

…, Y Ikeda, Y Ito, T Miyoshi, T Naito, O Miyata

Index: Ueda, Masafumi; Sugita, Shoichi; Aoi, Naoki; Sato, Aoi; Ikeda, Yuki; Ito, Yuta; Miyoshi, Tetsuya; Naito, Takeaki; Miyata, Okiko Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 9 p. 1206 - 1208

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Citation Number: 3

Abstract

The synthetic utility of N-alkoxyimidoyl halides is demonstrated using the palladium- catalyzed cross-coupling reaction. The Sonogashira and Suzuki–Miyaura coupling reactions of N-alkoxyimidoyl bromides produced versatile ketoxime ethers in good to excellent yields. A one-pot reaction of the imidoyl bromides with arylboronic acid and allylmagnesium bromide to produce N-arylamines via Suzuki–Miyaura coupling followed by domino ...