Synthesis of (±) Travoprost and its Analogs

…, S Madhavaram, L Tatini, GV Subbaraju

Index: Mudduluru, Harikrishna; Hindupur, Rama M.; Dubey, Pramod K.; Madhavaram, Shankar; Tatini, Lakshmikumar; Subbaraju, Gottumukkala V. Letters in Organic Chemistry, 2011 , vol. 8, # 4 p. 234 - 241

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Citation Number: 3

Abstract

A new synthetic approach for the antiglaucoma agent, travoprost (1) has been developed in four steps from key intermediate (2). Key transformations include Horner-Wadsworth- Emmons reaction and separation of diastereomers to obtain (±) travoprost (1) and its analogs.