Photo-inducible cytotoxic and clastogenic activities of 3, 6-di-substituted acridines obtained by acylation of proflavine

…, C Di Giorgio, G Boyer, AS Sabatier, D Allegro…

Index: Benchabane, Yohann; Di Giorgio, Carole; Boyer, Gerard; Sabatier, Anne-Sophie; Allegro, Diane; Peyrot, Vincent; De Meo, Michel European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2459 - 2467

Full Text: HTML

Citation Number: 19

Abstract

The cytotoxicity and photo-enhanced cytotoxicity of a series of 18 3, 6-di-substituted acridines were evaluated on both tumour CHO cells and human normal keratinocytes, and compared to their corresponding clastogenicity as assessed by the micronucleus assay. Compounds 2ftert-butyl N-[(6-tert-butoxycarbonylamino) acridin-3-yl] carbamate and 2dN-[6- (pivalamino) acridin-3-yl] pivalamide displayed a specific cytotoxicity on CHO cells. These ...