Tetrahedron letters

Reactions of 2-methylthiazolines and N-methyl cyclic ketene-N, S-acetals with acid chlorides

A Zhou, CU Pittman

Index: Zhou, Aihua; Pittman, Charles U. Tetrahedron Letters, 2004 , vol. 45, # 48 p. 8899 - 8903

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Citation Number: 23

Abstract

Carbon–carbon bond formation occurs under mild conditions when 2-methylthiazolines react with acid chlorides to form N-acyl-β-keto cyclic ketene-N, S-acetals. N-Methyl cyclic ketene-N, S-acetals, generated from 2-methyl-thiazolines, can react further with acid chlorides to form N-methyl-β-keto cyclic ketene-N, S-acetals.