Flash vacuum pyrolysis of stabilised phosphorus ylides. Part 17. 1 Preparation of aliphatic amino acid derived γ-alkoxycarbonylamino-β-oxo ylides and pyrolysis to …

…, N Karodia, T Massil, RJ Young

Index: Aitken, R. Alan; Karodia, Nazira; Massil, Tracy; Young, Robert J. Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 4 p. 533 - 541

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Citation Number: 3

Abstract

As noted in Tables 1 and 3, both the chiral acetylenic esters and their ylide precursors showed substantial optical rotations. However no satisfactory method for direct determination of the ee of these compounds has yet been found. For 16 and its pyrolysis product 28 where an additional stereogenic centre is present the absence of diastereomer signals in the NMR spectra indicated that no significant degree of racemisation had occurred. An alternative to the method ...