Tetrahedron Letters

One-step method for synthesis of 2, 4-disubstituted quinazoline 3-oxides by reaction of a 2-aminoaryl ketone with a hydroxamic acid using Zn (OTf) 2 as the catalyst

S Madabhushi, KKR Mallu, R Jillella, S Kurva…

Index: Madabhushi, Sridhar; Mallu, Kishore Kumar Reddy; Jillella, Raveendra; Kurva, Srinivas; Singh, Rajpal Tetrahedron Letters, 2014 , vol. 55, # 12 p. 1979 - 1982

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Citation Number: 5

Abstract

2,4-Disubstituted quinazoline 3-oxides are pharmacologically important as bronchodialators, 1 cardiotonics, 2 and fungicides, 3 and they are also important building blocks in organic synthesis. 4 Particularly, 2-chloromethyl quinazoline 3-oxides have high importance in the preparation of 1,4-benzodiazepine 4-oxides, for example chlordiazepoxide(Librium®), and 1,4-benzodiazepine, diazepam(Valium®), which are valuable drugs for the treatment ...