Journal of medicinal chemistry

Coenzyme Q. 139. Synthesis of new alkylamino-and alkylaminomethyl-5, 8-quinolinequinones as inhibitors of coenzyme Q and as antimalarials

TH Porter, FS Skelton, K Folkers

Index: Porter,T.H. et al. Journal of Medicinal Chemistry, 1972 , vol. 15, p. 34 - 36

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Citation Number: 15

Abstract

R=(CH,),, CH, appeared to dissolve before precipitation of the product in high yield occurred. After stirring at room temp, the reaction mixture was filtered, and the product was recrystallized to give a dark red powder. Antimalarial Test Results. These compounds were tested for antimalarial activity against P. berghei in miceI2 and against P. gallinaceum in the infected mosquito (Aedes aegypti). l2 A single dose at the desired level is given sc 72 hr ...