Synthesis of β??D??Galp??(1⇄ 4)?螃漫?D??GlcpNAc??(1⇄ 2)?螃窿?D??Manp??(1⇄ O)(CH2) 7CH3 Mimics to Explore the Substrate Specificity of Sialyltransferases and trans?? …

…, B Evers, RP Summeren, JP Kamerling…

Index: Joosten, John A. F.; Evers, Britta; Van Summeren, Ruben P.; Kamerling, Johannis P.; Vliegenthart, Johannes F. G. European Journal of Organic Chemistry, 2003 , # 18 p. 3569 - 3586

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Citation Number: 18

Abstract

Abstract Eleven trisaccharide octyl glycosides related to the N-glycan sequence β-D-Galp- (1⇄ 4)-β-D-GlcpNAc-(1⇄ 2)-α-D-Manp-(1⇄ O)(CH 2) 7 CH 3 (1) designed for detailed exploration of the acceptor specificity of α-2, 3-and α-2, 6-sialyltransferases as well as trans- sialidases, have been synthesised: β-D-Galp-(1⇄ 4)-β-D-GlcpNPr-(1⇄ 2)-α-D-Manp-(1⇄ O)(CH 2) 7 CH 3 (2), β-D-Fucp-(1⇄ 4)-β-D-GlcpNR-(1⇄ 2)-α-D-Manp-(1⇄ O)(CH 2) 7 CH 3 ...