Tetrahedron

Design and reactivity of organic functional groups-preparation and nucleophilic displacement reactions of imidazole-1-sulfonates (imidazylates)

JM Vatèle, S Hanessian

Index: Vatele, Jean-Michel; Hanessian, Stephen Tetrahedron, 1996 , vol. 52, # 32 p. 10557 - 10568

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Citation Number: 34

Abstract

Imidazole-1-sulfonate, a new type of leaving group by remote activation, allows facile SN2 substitution reactions at sterically crowded centers with various nucleophiles under mild conditions. It could be easily prepared from alcohols with cheap reagents in quantitative yield.

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