A solid-phase approach to DDB derivatives

X Qi, X Wang, L Wang, Q Wang, S Cheng, J Suo…

Index: Qi, Xiuxiang; Wang, Xiaolai; Wang, Limin; Wang, Qiang; Cheng, Senxiang; Suo, Jishuan; Chang, Junbiao European Journal of Medicinal Chemistry, 2005 , vol. 40, # 8 p. 805 - 810

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Citation Number: 15

Abstract

Since the discovery of 2, 2′-dimethoxycarbonyl-4, 4-dimethoxy-5, 6, 5′, 6′- biomethylenedioxy-biphenyl (DDB) as a potent anti-HBV agent, we have studied the structure–activity relationships of 4, 4′-dimethoxy-5, 6, 5′, 6′-dimethenedioxy-2- alkyloxycarbonyl-2′-(4-substituted benzyl piperazin-1-yl) carbonyl-biphenyl as anti-HBV agents. Therefore, it is rational to extend this study to the 3, 3′-disustituted-4, 4′- ...