Advanced Synthesis & Catalysis

Green and Scalable Aldehyde??Catalyzed Transition Metal??Free Dehydrative N??Alkylation of Amides and Amines with Alcohols

Q Xu, Q Li, X Zhu, J Chen

Index: Xu, Qing; Li, Qiang; Zhu, Xiaogang; Chen, Jianhui Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 73 - 80

Full Text: HTML

Citation Number: 36

Abstract

Abstract In contrast to the borrowing hydrogen-type N-alkylation reactions, in which alcohols were activated by transition metal-catalyzed anaerobic dehydrogenation, the addition of external aldehydes was accidentally found to be a simple and effective protocol for alcohol activation. This interesting finding subsequently led to an efficient and green, practical and scalable aldehyde-catalyzed transition metal-free dehydrative N-alkylation method for a ...

~96%

Detail

~88%

Glycerol ingrained copper: an efficient recyclable catalyst ...

[Khatri, Praveen K.; Jain, Suman L. Tetrahedron Letters, 2013 , vol. 54, # 21 p. 2740 - 2743]

Rapid and convenient approach to amines: Reduction of imines...

[Mitoma, Yoshiharu; Egashira, Naoyoshi; Simion, Cristian; Tashiro, Masashi Revue Roumaine de Chimie, 2006 , vol. 51, # 7-8 p. 839 - 842]

One-pot synthesis of indoles and aniline derivatives from ni...

[Yamane, Yoshihiro; Liu, Xiaohao; Hamasaki, Akiyuki; Ishida, Tamao; Haruta, Masatake; Yokoyama, Takushi; Tokunaga, Makoto Organic Letters, 2009 , vol. 11, # 22 p. 5162 - 5165]

Iron-catalyzed oxidative tandem reactions with TEMPO oxoammo...

[Marzaro, Giovanni; Guiotto, Adriano; Chilin, Adriana Green Chemistry, 2009 , vol. 11, # 6 p. 774 - 776]

Direct reductive amination of aldehydes using lithium-arene ...

[Nador, Fabiana; Moglie, Yanina; Ciolino, Andres; Pierini, Adriana; Dorn, Viviana; Yus, Miguel; Alonso, Francisco; Radivoy, Gabriel Tetrahedron Letters, 2012 , vol. 53, # 25 p. 3156 - 3160]