Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics

J Schoepfer, H Fretz, B Chaudhuri…

Index: Sarbagya, D. P.; Rangachari, K.; Mazumdar, A. K. D.; Banerji, K. D. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 891 - 893

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Citation Number: 91

Abstract

... Journal of Medicinal ... Oncology Research, NOVARTIS Pharma AG, 4002 Basle, Switzerland. J. Med. Chem. ... Table 1. Binding Energies (kcal/mol) for Benzofuranone Mimics and Flavopiridol. no. R 1, R 2, E binding a. 4, H, H, −17.8. 5, H, Cl, −16.0. 6, NO 2, H, −19.0. 7, SO 2 NH 2, H, ...