Tetrahedron letters

Synthesis of diarylazepan-4-ones

MY Chang, YH Kung, CC Ma

Index: Chang, Meng-Yang; Kung, Yung-Hua; Ma, Chih-Chong Tetrahedron Letters, 2007 , vol. 48, # 2 p. 199 - 202

Full Text: HTML

Citation Number: 12

Abstract

Synthesis of several 3, 3-diarylazepan-4-ones and 5, 5-diarylazepan-4-ones has been established starting from two tetrasubstituted olefins, which is derived from commercially available piperidine-3-carboxylic acid ethyl ester and piperidine-4-carboxylic acid ethyl ester. The single isomer with the structural skeleton of 3, 3-diarylazepan-4-one and 5, 5- diarylazepan-4-one is constructed in two functional group transformations of Grignard ...

 Related Synthetic Route
phenyl(1-(phenylsulfonyl)piperidin-4-yl)methanol Structure

216087-82-0

phenyl(1-(pheny...

~%

[1-(benzenesulfonyl)piperidin-4-yl]-phenylmethanone Structure

922504-25-4

[1-(benzenesulf...

Ethyl Isonipecotate Structure

1126-09-6

Ethyl Isonipecotate

~%

[1-(benzenesulfonyl)piperidin-4-yl]-phenylmethanone Structure

922504-25-4

[1-(benzenesulf...

N/A Structure

216087-81-9

N/A

~%

[1-(benzenesulfonyl)piperidin-4-yl]-phenylmethanone Structure

922504-25-4

[1-(benzenesulf...

ETHYL 1-(PHENYLSULFONYL)-4-PIPERIDINECARBOXYLATE Structure

111627-26-0

ETHYL 1-(PHENYL...

~%

[1-(benzenesulfonyl)piperidin-4-yl]-phenylmethanone Structure

922504-25-4

[1-(benzenesulf...

(1-Benzoyl-[4]piperidyl)-phenyl-methanol Structure

109932-47-0

(1-Benzoyl-[4]p...

~%

PIPERIDINE-1,4-DIYLBIS(PHENYLMETHANONE) Structure

109555-51-3

PIPERIDINE-1,4-...

Ethyl Isonipecotate Structure

1126-09-6

Ethyl Isonipecotate

~%

PIPERIDINE-1,4-DIYLBIS(PHENYLMETHANONE) Structure

109555-51-3

PIPERIDINE-1,4-...

[4-(hydroxymethyl)piperidin-1-yl]-phenylmethanone Structure

19980-00-8

[4-(hydroxymeth...

~%

PIPERIDINE-1,4-DIYLBIS(PHENYLMETHANONE) Structure

109555-51-3

PIPERIDINE-1,4-...

1-BENZOYL-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER Structure

136081-74-8

1-BENZOYL-PIPER...

~%

PIPERIDINE-1,4-DIYLBIS(PHENYLMETHANONE) Structure

109555-51-3

PIPERIDINE-1,4-...

Benzoyl chloride Structure

98-88-4

Benzoyl chloride

~%

PIPERIDINE-1,4-DIYLBIS(PHENYLMETHANONE) Structure

109555-51-3

PIPERIDINE-1,4-...

1-benzoylpiperidine-4-carbaldehyde Structure

120014-29-1

1-benzoylpiperi...

~%

PIPERIDINE-1,4-DIYLBIS(PHENYLMETHANONE) Structure

109555-51-3

PIPERIDINE-1,4-...

ETHYL 1-[(4-METHYLPHENYL)SULFONYL]-4-PIPERIDINECARBOXYLATE Structure

297180-07-5

ETHYL 1-[(4-MET...

~%

[1-(4-methylphenyl)sulfonylpiperidin-4-yl]-phenylmethanone Structure

922504-26-5

[1-(4-methylphe...

Ethyl Isonipecotate Structure

1126-09-6

Ethyl Isonipecotate

~%

[1-(4-methylphenyl)sulfonylpiperidin-4-yl]-phenylmethanone Structure

922504-26-5

[1-(4-methylphe...

Tosyl chloride Structure

98-59-9

Tosyl chloride

~%

[1-(4-methylphenyl)sulfonylpiperidin-4-yl]-phenylmethanone Structure

922504-26-5

[1-(4-methylphe...

1-[(4-methylphenyl)sulfonyl]piperidine-4-carbaldehyde Structure

553666-09-4

1-[(4-methylphe...

~%

[1-(4-methylphenyl)sulfonylpiperidin-4-yl]-phenylmethanone Structure

922504-26-5

[1-(4-methylphe...

{1-[(4-methylphenyl)sulfonyl]piperidin-4-yl}methanol Structure

582299-09-0

{1-[(4-methylph...

~%

[1-(4-methylphenyl)sulfonylpiperidin-4-yl]-phenylmethanone Structure

922504-26-5

[1-(4-methylphe...

benzyl 4-(hydroxy(phenyl)methyl)piperidine-1-carboxylate Structure

1013329-95-7

benzyl 4-(hydro...

~%

benzyl 4-benzoylpiperidine-1-carboxylate Structure

922504-27-6

benzyl 4-benzoy...

Ethyl Isonipecotate Structure

1126-09-6

Ethyl Isonipecotate

~%

benzyl 4-benzoylpiperidine-1-carboxylate Structure

922504-27-6

benzyl 4-benzoy...

4-Formyl-N-Cbz-piperidine Structure

138163-08-3

4-Formyl-N-Cbz-...

~%

benzyl 4-benzoylpiperidine-1-carboxylate Structure

922504-27-6

benzyl 4-benzoy...

Ethyl N-Cbz-piperidine-4-carboxylate Structure

160809-38-1

Ethyl N-Cbz-pip...

~%

benzyl 4-benzoylpiperidine-1-carboxylate Structure

922504-27-6

benzyl 4-benzoy...

1-Cbz-4-Hydroxymethylpiperidine Structure

122860-33-7

1-Cbz-4-Hydroxy...

~%

benzyl 4-benzoylpiperidine-1-carboxylate Structure

922504-27-6

benzyl 4-benzoy...

Ethyl Isonipecotate Structure

1126-09-6

Ethyl Isonipecotate

~%

(1-(methylsulfonyl)piperidin-4-yl)methanol Structure

241134-34-9

(1-(methylsulfo...

ETHYL 1-[(4-METHYLPHENYL)SULFONYL]-4-PIPERIDINECARBOXYLATE Structure

297180-07-5

ETHYL 1-[(4-MET...

~%

1-(4-methylphenyl)sulfonyl-5,5-diphenylazepan-4-one Structure

922504-30-1

1-(4-methylphen...

[1-(4-methylphenyl)sulfonylpiperidin-4-yl]-phenylmethanone Structure

922504-26-5

[1-(4-methylphe...

~%

1-(4-methylphenyl)sulfonyl-5,5-diphenylazepan-4-one Structure

922504-30-1

1-(4-methylphen...

Ethyl Isonipecotate Structure

1126-09-6

Ethyl Isonipecotate

~%

1-(4-methylphenyl)sulfonyl-5,5-diphenylazepan-4-one Structure

922504-30-1

1-(4-methylphen...

Tosyl chloride Structure

98-59-9

Tosyl chloride

~%

1-(4-methylphenyl)sulfonyl-5,5-diphenylazepan-4-one Structure

922504-30-1

1-(4-methylphen...

1-[(4-methylphenyl)sulfonyl]piperidine-4-carbaldehyde Structure

553666-09-4

1-[(4-methylphe...

~%

1-(4-methylphenyl)sulfonyl-5,5-diphenylazepan-4-one Structure

922504-30-1

1-(4-methylphen...

{1-[(4-methylphenyl)sulfonyl]piperidin-4-yl}methanol Structure

582299-09-0

{1-[(4-methylph...

~%

1-(4-methylphenyl)sulfonyl-5,5-diphenylazepan-4-one Structure

922504-30-1

1-(4-methylphen...

ETHYL 1-(METHYLSULFONYL)-4-PIPERIDINECARBOXYLATE Structure

217487-18-8

ETHYL 1-(METHYL...

~%

(1-methylsulfonylpiperidin-4-yl)-phenylmethanone Structure

515154-31-1

(1-methylsulfon...

1-Methanesulfonyl-piperidine-4-carbaldehyde Structure

241134-35-0

1-Methanesulfon...

~%

(1-methylsulfonylpiperidin-4-yl)-phenylmethanone Structure

515154-31-1

(1-methylsulfon...

(1-(methylsulfonyl)piperidin-4-yl)methanol Structure

241134-34-9

(1-(methylsulfo...

~%

(1-methylsulfonylpiperidin-4-yl)-phenylmethanone Structure

515154-31-1

(1-methylsulfon...

Ethyl Isonipecotate Structure

1126-09-6

Ethyl Isonipecotate

~%

(1-methylsulfonylpiperidin-4-yl)-phenylmethanone Structure

515154-31-1

(1-methylsulfon...

Ethyl Isonipecotate Structure

1126-09-6

Ethyl Isonipecotate

~%

1-benzoylpiperidine-4-carbaldehyde Structure

120014-29-1

1-benzoylpiperi...

1-BENZOYL-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER Structure

136081-74-8

1-BENZOYL-PIPER...

~%

1-benzoylpiperidine-4-carbaldehyde Structure

120014-29-1

1-benzoylpiperi...

Benzoyl chloride Structure

98-88-4

Benzoyl chloride

~%

1-benzoylpiperidine-4-carbaldehyde Structure

120014-29-1

1-benzoylpiperi...

Ethyl Isonipecotate Structure

1126-09-6

Ethyl Isonipecotate

~%

[4-(hydroxymethyl)piperidin-1-yl]-phenylmethanone Structure

19980-00-8

[4-(hydroxymeth...

(1-METHANESULFONYLPIPERIDIN-3-YL)METHANOL Structure

349403-27-6

(1-METHANESULFO...

~%

(1-methylsulfonylpiperidin-3-yl)-phenylmethanone Structure

922504-15-2

(1-methylsulfon...

1-METHANESULFONYL-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER Structure

349625-89-4

1-METHANESULFON...

~%

(1-methylsulfonylpiperidin-3-yl)-phenylmethanone Structure

922504-15-2

(1-methylsulfon...

ethyl nipecotate Structure

71962-74-8

ethyl nipecotate

~%

(1-methylsulfonylpiperidin-3-yl)-phenylmethanone Structure

922504-15-2

(1-methylsulfon...

(1-METHANESULFONYLPIPERIDIN-3-YL)METHANOL Structure

349403-27-6

(1-METHANESULFO...

~%

(2-methylphenyl)-(1-methylsulfonylpiperidin-3-yl)methanone Structure

922504-16-3

(2-methylphenyl...

1-METHANESULFONYL-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER Structure

349625-89-4

1-METHANESULFON...

~%

(2-methylphenyl)-(1-methylsulfonylpiperidin-3-yl)methanone Structure

922504-16-3

(2-methylphenyl...

ethyl nipecotate Structure

71962-74-8

ethyl nipecotate

~%

(2-methylphenyl)-(1-methylsulfonylpiperidin-3-yl)methanone Structure

922504-16-3

(2-methylphenyl...

(1-METHANESULFONYLPIPERIDIN-3-YL)METHANOL Structure

349403-27-6

(1-METHANESULFO...

~%

(4-methoxyphenyl)-(1-methylsulfonylpiperidin-3-yl)methanone Structure

922504-17-4

(4-methoxypheny...

1-METHANESULFONYL-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER Structure

349625-89-4

1-METHANESULFON...

~%

(4-methoxyphenyl)-(1-methylsulfonylpiperidin-3-yl)methanone Structure

922504-17-4

(4-methoxypheny...

ethyl nipecotate Structure

71962-74-8

ethyl nipecotate

~%

(4-methoxyphenyl)-(1-methylsulfonylpiperidin-3-yl)methanone Structure

922504-17-4

(4-methoxypheny...


Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved