The Journal of Organic Chemistry

Thiosugars. I. Synthesis of Derivatives of 2-Amino-2-deoxy-1-thio-D-glucose1

D Horton, ML Wolfrom

Index: Horton,D.; Wolfrom,M.L. Journal of Organic Chemistry, 1962 , vol. 27, p. 1794 - 1800

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Citation Number: 120

Abstract

The known effectiveness of 8-and y-aminothiol systems in protecting living tissue from damage by ionizing radiation2 suggested that a carbohydrate molecule containing these functional groups might also have radiation protective ability, and at the same time be more physiologically acceptable than noncarbohydrate analogs, most of which are fairly toxic. Derivatives containing the 3-amino-3-deoxy-2-thio-~-al1ose~ and 3-amino-3-deoxy-2-thio ...