New functionalised silicas for highly selective cation exchange SPE purification in medicinal chemistry

J Brown, A Chighine, MA Colucci, N Galaffu, SC Hirst…

Index: Brown, Jane; Chighine, Alessandra; Colucci, Marie A.; Galaffu, Nicola; Hirst, Simon C.; Seymour, Helen M.; Shiers, Jason J.; Wilkes, Robin D.; Williams, Jonathan G.; Wilson, John R.H. Tetrahedron Letters, 2008 , vol. 49, # 33 p. 4968 - 4971

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Citation Number: 5

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Functionalised silicas 2 and 3 are effective for the cation exchange SPE purification of basic molecules containing acid-sensitive functionalities, the selective separations of mixtures of basic compounds and accelerated reaction work-ups/product isolations. ... Functionalised silicas 2 and 3 are effective for ...