Influence of polarity on the scalability and reproducibility of solvent-free microwave-assisted reactions

A Díaz-Ortiz, A de la Hoz, J Alcázar…

Index: Diaz-Ortiz, Ange; De La Hoz, Antonio; Alcazar, Jesus; Carrillo, Jose R.; Herrero, Maria A.; Fontana, Alberto; Munoz, Juan De M.; Prieto, Pilar; De Cozar, Abel Combinatorial Chemistry and High Throughput Screening, 2011 , vol. 14, # 2 p. 109 - 116

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Citation Number: 4

Abstract

Organic reactions performed in the absence of solvent in domestic ovens without appropriate temperature control are generally considered as not reproducible, particularly when different instruments are used. For this reason, reproducibility has historically been one of the major issues associated with Microwave-Assisted Organic Synthesis (MAOS) especially when domestic ovens are involved. The lack of reproducibility limits the general ...