Synthesis of (S)-(−)-N-acetylcolchinol using intramolecular biaryl oxidative coupling

…, K Jarowicki, PJ Kocienski, E Sliwinski…

Index: Besong, Gilbert; Jarowicki, Krzysztof; Kocienski, Philip J.; Sliwinski, Eric; Boyle, F. Thomas Organic and Biomolecular Chemistry, 2006 , vol. 4, # 11 p. 2193 - 2207

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Citation Number: 68

Abstract

An asymmetric synthesis of the tubulin polymerisation inhibitor (S)-(−)-N-acetylcolchinol is reported based on an intramolecular biaryl oxidative coupling of a 1, 3-diarylpropyl acetamide intermediate using phenyliodonium bis (trifluoroacetate) as the final step. Three syntheses of the penultimate 1, 3-diarylpropyl acetamide intermediate (S)-(−)-N-[1-[3-(tert- butyldimethylsilyloxy) phenyl)]-3-(3, 4, 5-trimethoxyphenyl) propyl] acetamide are ...