Synthesis and biological activity of ω-substituted 2-alkylthio-4, 6-dimethylpyrimidines

…, NG Pashkurov, VS Reznik, TY Makhan'ko…

Index: Mikhailov, A. S.; Pashkurov, N. G.; Reznik, V. S.; Makhan'ko, T. Yu.; Zobov, V. V.; Gorbunov, S. M. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 1 p. 46 - 48 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 1 p. 64 - 67

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Abstract

In continuation of work on the reactions of (Ia-c) with nucleophiles, and in order to establish the dependence of bioloigcal activity on the structures of these compounds, we have examined the reactions of (Ia-c) with a variety of famines. It was found that, irrespective of the type of amine, only the compounds (IIa-g) were obtained, in high yields. Thus, reaction of (Ia- c) with pyridine, and of (Ib) with triethyiamine in solution in methyl ethyl ketone afforded ( ...