Abstract Chiral oxazolidines obtained by condensation of aldehydes with (-).(R)-or (+).(S)-N- benzylphenylglycinol react with the Reformatsky reagent derived from ethyl bromoacetate, in mild reaction conditions (Et 2 O or CH 2 Cl 2, 0 C, 15-60 min), leading to ethyl β-amino carboxylates in moderate to good diastereomeric excess (60-92%). These ring opening products are transformed into primary β-aminoesters, in one step, by debenzylation with H ...
