The Candida antarctica lipase B-catalyzed reactions of five β-amino esters with neat butyl butanoate and with 2, 2, 2-trifluoroethyl butanoate in diisopropyl ether were studied, as were the reactions of the same β-amino esters and their N-butanamides with neat butanol. The possibility for sequential resolution, where the amino and ester functions of the substrate both react with an achiral butanoate, became less likely with increasing size of the ...
