Synthetic Communications

Preparation of Phosphonoterephthalic Acids via Palladium-Catalyzed Coupling of Aromatic Iodoesters

N Ivan, V Benin, AB Morgan

Index: Ivan, Nathaniel; Benin, Vladimir; Morgan, Alexander B. Synthetic Communications, 2013 , vol. 43, # 13 p. 1831 - 1836

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Citation Number: 3

Abstract

The current article reports in detail the preparation of two phosphonoterephthalic acids: 2-phosphonoterephthalic acid (1) and 2,5-diphosphonoterephthalic acid (2). Efficient, scalable syntheses have been developed for both compounds based on Pd-catalyzed coupling reactions of iodinated terephthalate esters. Phosphonoterephthalic acids are potentially useful as flame-retardant additives or as monomers for the construction of acid-pendant polymer chains.