Synthesis of 4-alkyl-2-iodosobenzoic acids: potent catalysts for the hydrolysis of phosphorus esters

CA Panetta, SM Garlick, HD Durst…

Index: Panetta, Charles A.; Garlick, Stephanie M.; Durst, H. Dupont; Longo, Frederick R.; Ward, J. Richard Journal of Organic Chemistry, 1990 , vol. 55, # 18 p. 5202 - 5205

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Citation Number: 36

Abstract

The syntheses of five new 4-alkyl-2-iodosobenzoic acids (3) are described. The iodine atom was introduced by ortho-directed lithiation of 4-alkylbenzyl alcohols followed by treatment with I*. The catalytic effectiveness of each of the products in the hydrolysis of 4-nitrophenyl diphenyl phosphate in microemulsions was studied. The 4-methyl-and 4-ethyl-substituted products were each found to be significantly better catalysts than the standard ...