Precursor??Directed Syntheses and Biological Evaluation of New Elansolid Derivatives

…, R Dehn, G Dräger, A Kirschning, R Müller

Index: Steinmetz, Heinrich; Zander, Wiebke; Shushni, Muftah A.M.; Jansen, Rolf; Gerth, Klaus; Dehn, Richard; Draeger, Gerald; Kirschning, Andreas; Mueller, Rolf ChemBioChem, 2012 , vol. 13, # 12 p. 1813 - 1817

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Citation Number: 11

Abstract

Abstract The antibiotic elansolid C1 (8) was isolated from Chitinophaga sancti strain FxGBF13 after fermentation in the presence of anthranilic acid. Remarkably, 8 was also obtained by addition of anthranilic acid to a crude fermentation extract containing the macrolide elansolid A2 (1*). This Michael-type conjugate addition allowed us to generate 21 new derivatives of elansolid C1 (9–29) by using various nucleophiles. Biological activities ...