Chemical Communications

Perchloric acid adsorbed on silica gel as a new, highly efficient, and versatile catalyst for acetylation of phenols, thiols, alcohols, and amines

AK Chakraborti, R Gulhane

Index: Chakraborti, Asit K.; Gulhane, Rajesh Chemical Communications, 2003 , # 15 p. 1896 - 1897

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Citation Number: 97

Abstract

The prevalence of phenol, thiol, alcohol, and amine functionalities in drugs and pharmaceuticals makes the protection of these functional groups a prime importance while carrying out reactions sensitive to such functionalities in a multifunctional substrate having one or more of these groups. Protection is usually achieved through acylation with anhydrides 1 due to the ease of deprotection. 1,2 The poor nucleophilicity of hydroxylic compounds, particularly phenols, ...