Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones

IO Edafiogho, OA Phillips, EE Udo, S Samuel…

Index: Edafiogho, Ivan O.; Phillips, Oludotun A.; Udo, Edet E.; Samuel, Santosh; Rethish, Beigy European Journal of Medicinal Chemistry, 2009 , vol. 44, # 3 p. 967 - 975

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Citation Number: 29

Abstract

Several cyclic enaminone esters were synthesized, characterized, and evaluated for anticonvulsant and antibacterial activities using standardized tests. A series of enaminones were mainly phenyl analogs of anticonvulsant enaminones, while a second series comprised of compounds bearing the oxazolidinone pharmacophoric moiety found in the synthetic antibacterial linezolid. The enaminone ester bearing an unsubstituted anilino ...