Glycerophosphorylcholine (GPC) is transformed into the cyclic stannylene derivatives, which are selectively acylated to 1-acyl-2-lyso-glycerophosphocholines. The reaction is effective using C-2 to C-16 acid chlorides in 2-propanol. After solvent replacement the lyso- phospholipid (lyso-PL) is subjected to a second acylation using acid anhydrides in methylene chloride. A series of 1 (2)-short-2 (1)-long-diacyl-glycerophosphocholines are ...
