Choline glycerophosphate

Modify Date: 2025-08-23 17:37:25

Choline glycerophosphate Structure
Choline glycerophosphate structure
 Common Name Choline glycerophosphate
CAS Number 28319-77-9 Molecular Weight 257.221
Density N/A Boiling Point N/A
Molecular Formula C8H20NO6P Melting Point -98ºC
MSDS USA Flash Point 11 °C

 Use of Choline glycerophosphate


L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and dementia.IC50 value:Target: Anti-ADAlpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer’s disease. An Italian multicentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2].

 Names

Name choline alfoscerate
Synonym More Synonyms

 Choline glycerophosphate Biological Activity

Description L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and dementia.IC50 value:Target: Anti-ADAlpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer’s disease. An Italian multicentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Parnetti L, et al. Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation J Neurol Sci. 2007 Jun 15;257(1-2):264-9.

[2]. Barbagallo Sangiorgi G, et al. Alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks." An Italian multicenter clinical trial. Ann NY Acad Sci 1994; 717:253-69.

 Chemical & Physical Properties

Melting Point -98ºC
Molecular Formula C8H20NO6P
Molecular Weight 257.221
Flash Point 11 °C
Exact Mass 257.102814
PSA 108.86000
LogP -5.63
Appearance of Characters solid
Index of Refraction 1.329 (20ºC)
InChIKey SUHOQUVVVLNYQR-MRVPVSSYSA-N
SMILES C[N+](C)(C)CCOP(=O)([O-])OCC(O)CO
Storage condition −20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KH2775000
CHEMICAL NAME :
Ethanaminium, 2-(((2,3-dihydroxypropoxy)hydroxyphosphinyl)oxy)-N,N, N-trimethyl-, hydroxide, inner salt, (R)-
CAS REGISTRY NUMBER :
28319-77-9
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H20-N-O6-P
MOLECULAR WEIGHT :
257.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>13 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-32553
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-32553

 Safety Information

Hazard Codes F: Flammable;T: Toxic;
Risk Phrases R11
Safety Phrases S16-S36/37-S45
RIDADR UN 1230 3/PG 2
WGK Germany 2
RTECS KH2775000
Packaging Group II
HS Code 2923900090

 Synthetic Route

Diacetyl-L-Glycerophosphorylcholine structure

Diacetyl-L-Glyc...

CAS#:54672-38-7

~92%

Choline glycerophosphate Structure

Choline glycero...

CAS#:28319-77-9

Literature: Park, Jong Moon; De Castro, Kathlia A.; Ahn, Hyunseok; Rhee, Hakjune Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 9 p. 2689 - 2691
N/A structure

N/A

CAS#:1417365-52-6

~%

N/A structure

N/A

CAS#:1426535-84-3

Choline glycerophosphate Structure

Choline glycero...

CAS#:28319-77-9

Literature: Nakamura, Yuichi; Kato, Hikaru; Nishikawa, Tadateru; Iwasaki, Noriyuki; Suwa, Yoshiaki; Rotinsulu, Henki; Losung, Fije; Maarisit, Wilmar; Mangindaan, Remy E. P.; Morioka, Hiroshi; Yokosawa, Hideyoshi; Tsukamoto, Sachiko Organic Letters, 2013 , vol. 15, # 2 p. 322 - 325

 Customs

HS Code 2923900090
Summary 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Synonyms

L-α-Glycerophosphocholine
α-GPC
Ethanaminium, 2-[[[(2R)-2,3-dihydroxypropoxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt
L-a-Glycerylphosphorylcholine
L-α-Glycerophosphorylcholine
Choline Alfoscerate
cholini alfosceras
(R)-2-[[(2,3-Dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium hydroxide inner salt
sn-Glycero-3-phosphocholine
(2R)-2,3-Dihydroxypropyl 2-(trimethylammonio)ethyl phosphate
MFCD00063544
alfoscerato de colina
EINECS 248-962-2
alfoscerate de choline
L-α Glycerylphosphorylcholine
L-a-GPC
sn-Glycero-3-phosphorylcholine
Choline glycerophosphate
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Choline glycerophosphate suppliers

Price: ￥38/250mg

Reference only. check more Choline glycerophosphate price

Related Compounds: More...
CHOLINE GLYCEROPHOSPHATE
563-23-5
tert-butyl N-[2-(2-chloro-4-fluorophenyl)-1-oxopropan-2-yl]-N-methylcarbamate
2228373-82-6
tert-butyl N-[1-(6-methoxypyridin-3-yl)-2-oxoethyl]carbamate
2229512-52-9
5,5-Dimethyl-1,3-oxazinane-2-carboxylic acid
2166906-63-2
3-(3-Bromo-2,4-dimethylphenyl)but-3-en-1-amine
2228994-07-6
tert-butyl N-{1-[1-(2-methylpropyl)-1H-pyrazol-5-yl]-2-oxoethyl}carbamate
2229109-32-2
methyl 4-(1-{[(tert-butoxy)carbonyl]amino}-2-oxoethyl)-1-methyl-1H-pyrazole-3-carboxylate
2228269-11-0
tert-butyl N-[2-(2,6-difluoro-3-nitrophenyl)-1-oxopropan-2-yl]carbamate
2228222-59-9
tert-butyl N-[2-(5,6-dichloropyridin-3-yl)-1-oxopropan-2-yl]carbamate
2229516-77-0
Benzoic acid, 2-phenyl-2-(2-thiazolyl)hydrazide
7709-60-6
3-(2,6-Difluoro-3-nitrophenyl)prop-2-enal
2229664-77-9
Chemsrc provides Choline glycerophosphate(CAS#:28319-77-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Choline glycerophosphate are included as well.>> amp version: Choline glycerophosphate

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved