Choline glycerophosphate
Modify Date: 2024-01-02 21:03:26
Choline glycerophosphate structure
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Common Name | Choline glycerophosphate | ||
|---|---|---|---|---|
| CAS Number | 28319-77-9 | Molecular Weight | 257.221 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C8H20NO6P | Melting Point | -98ºC | |
| MSDS | USA | Flash Point | 11 °C | |
Use of Choline glycerophosphateL-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and dementia.IC50 value:Target: Anti-ADAlpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer’s disease. An Italian multicentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2]. |
| Name | choline alfoscerate |
|---|---|
| Synonym | More Synonyms |
| Description | L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and dementia.IC50 value:Target: Anti-ADAlpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer’s disease. An Italian multicentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| References |
| Melting Point | -98ºC |
|---|---|
| Molecular Formula | C8H20NO6P |
| Molecular Weight | 257.221 |
| Flash Point | 11 °C |
| Exact Mass | 257.102814 |
| PSA | 108.86000 |
| LogP | -5.63 |
| Appearance of Characters | solid |
| Index of Refraction | 1.329 (20ºC) |
| Storage condition | −20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | F: Flammable;T: Toxic; |
|---|---|
| Risk Phrases | R11 |
| Safety Phrases | S16-S36/37-S45 |
| RIDADR | UN 1230 3/PG 2 |
| WGK Germany | 2 |
| RTECS | KH2775000 |
| Packaging Group | II |
| HS Code | 2923900090 |
|
~92%
Choline glycero... CAS#:28319-77-9 |
| Literature: Park, Jong Moon; De Castro, Kathlia A.; Ahn, Hyunseok; Rhee, Hakjune Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 9 p. 2689 - 2691 |
|
~%
Choline glycero... CAS#:28319-77-9 |
| Literature: Nakamura, Yuichi; Kato, Hikaru; Nishikawa, Tadateru; Iwasaki, Noriyuki; Suwa, Yoshiaki; Rotinsulu, Henki; Losung, Fije; Maarisit, Wilmar; Mangindaan, Remy E. P.; Morioka, Hiroshi; Yokosawa, Hideyoshi; Tsukamoto, Sachiko Organic Letters, 2013 , vol. 15, # 2 p. 322 - 325 |
| HS Code | 2923900090 |
|---|---|
| Summary | 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
| L-α-Glycerophosphocholine |
| α-GPC |
| Ethanaminium, 2-[[[(2R)-2,3-dihydroxypropoxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt |
| L-a-Glycerylphosphorylcholine |
| L-α-Glycerophosphorylcholine |
| Choline Alfoscerate |
| cholini alfosceras |
| (R)-2-[[(2,3-Dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium hydroxide inner salt |
| sn-Glycero-3-phosphocholine |
| (2R)-2,3-Dihydroxypropyl 2-(trimethylammonio)ethyl phosphate |
| MFCD00063544 |
| alfoscerato de colina |
| EINECS 248-962-2 |
| alfoscerate de choline |
| L-α Glycerylphosphorylcholine |
| L-a-GPC |
| sn-Glycero-3-phosphorylcholine |
| Choline glycerophosphate |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Choline glycerophosphate
- Price: ￥958.0/5g ￥328.0/1g
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Choline Alfoscerate
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Choline glycerophosphate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: choline alfoscerate
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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Price: ￥38/250mg
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